Hypoxia-inducible adrenomedullin in colorectal cancer.
نویسندگان
چکیده
BACKGROUND Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. PATIENTS AND METHODS To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n = 222), and quantitative reverse-transcriptase polymerase chain reaction (n = 151). RESULTS ADM was a novel independent prognostic factor for CRC (p = 0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p < 0.0001) and vascular endothelial growth factor (p < 0.0001) in vivo. CONCLUSION ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.
منابع مشابه
Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes.
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عنوان ژورنال:
- Anticancer research
دوره 31 2 شماره
صفحات -
تاریخ انتشار 2011